G=B.Axis - Phosphatidylserine, DHA, Probiotic Blend, B3, B6, Folate, B12 - 30 caps.

G≡B.axis  

Exclusive combination of probiotics, vitamins and DHA-Phosphatidylserine, with synergistic action for Gut-Brain Axis modulation and balance.

G≡B Axis can be used in any situation, in isolation or in combination, it is safe to use with anti-depressants, anxiolytics and sedatives of any source (pharmaceuticals and/or dietary supplements), filling therapeutic gaps and complementing actions of any of these agents.

The Phosphatidylserine-DHA complex in G≡B Axis promotes integrity of neural structures and signaling, in a highly bioavailable formula, increasing its concentration in brain tissues, supporting memory and cognitive function.

G≡B Axis is composed of a unique combination of 5 strains of probiotics, specifically chosen for their ability to survive the digestive process and their high colonisation ability, which modulate the stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequent onset of mood/stress/depression/anxiety/sleep changes, acting on the neuroendocrine system.

The combination of B-complex and Vitamin D has been shown to be an adjunctive and effective strategy, that is well tolerated to improve the symptoms of depression and anxiety. Phosphatidylserine-DHA

Complex Phosphatidylserine (PS) conjugated with DHA is a combination of two fatty acids, the docosahexaenoic acid (DHA) and phosphatidylserine. This combination can be used with many health benefits, including:

• improved cognitive function,
• the ability to memorize,
• improved mood,
• reduced stress,
• increased concentration,
• sleep quality,
• cardiovascular health,
• improving joint health,
• as well as helping to reduce inflammation,
• the risk of Alzheimer's or suffering a stroke.

Indicators from 2020 showed that the combined use of DHA and PS relieves cognitive impairment, especially that which has been induced by the accumulation of beta-amyloid peptide (Aβ), obtaining better results than the DHA-Phosphatidylserine combination.

G≡B.axis

Probiotic Blend

Probiotics are used in modulation of the gut-brain axis and it has been proven that these have supportive impact on the central nervous system and decrease, or controls the incidence of some mental disorders, such as depression, anxiety, autism, schizophrenia and Alzheimer's disease.

The gut microbiome (GM) is a factor that influences mood status, via your connection to the gut-brain axis and it is recognized that gut dysbiosis harms mental health, leading to health disorders by disrupting the microbiome.

Cognitive and mood changes (as well as depressive and/or anxious symptoms, changes in sleeping patterns, other cognitive and learning or attention shifts), are usually associated with gastro-intestinal disease (GIT), tract disorders such as inflammatory bowel disease, metabolic syndrome and irritable bowel syndrome.

The gut microbiota can directly affect the brain tissue, regulating the secretion of hormones that produce cerebro-intestinal peptides, intestinal endocrine cells, corticotropin, corticotropin factor release, leptin and adrenocortical ketones.

Probiotics have a potential impact on depressive behavior through their ability to restore cortisol levels, attenuate inflammatory mediators and regulate the synthesis of serotonin and CNS transmitters.

Taking probiotics can improve the quality of of sleep, which is related to the balance of the GM. The significant bidirectional relationship between the GIT and the CNS (gut-brain axis) plays an important role in the regulation of GM composition and, therefore, supplementation with probiotics can help improve sleep quality, by maintaining the balance of the GM environment.

Hence there are several conditions in which probiotic supplementation is helpful (in addition to besides depression, stress, anxiety and sleep) such as Alzheimer's, autism, hyperactivity with/or attention deficit, schizophrenia, among others.

Supplementation with probiotics significantly improves symptoms in individuals with depression, including improvement in the quality of sleep, mood, and the ability to feel pleasure.

B3, B6, Folate and B12

B Vitamins play an interrelated role in the maintenance of our brain function. Adequate quantities of B vitamins in the body are essential for optimal physiological and neurological function. B Vitamins are essential for a healthy and balanced microbiome.

Individuals with brain fog exhibit a number of neurological symptoms, such as difficulty maintaining attention or concentration, a sensation of sluggish cognition, memory alterations, and various psychiatric symptoms that are associated with B3 deficiency.

Niacin can be used to treat some types of schizophrenia, given its ability to recover existing brain cell damage. Various investigations show that it can help keep the brain healthy in cases of Alzheimer's and Parkinson’s disease.

Vitamin B6 plays a role in cognitive development through biosynthesis of neurotransmitters and in the regulation of mood. It is essential to lower homocysteine levels, depression, and other psychiatric disorders. Low levels of B6 in children and adults provokes depressive states and supplementation with the vitamin can improve cognitive states, decrease risk of Alzheimer's, anxiety and premenstrual period syndrome, and its usefulness is even greater when combined with other B vitamins.

Folate (Vitamin B9) promotes conversion of homocysteine to methionine, synthesis of S-adenosyl-methionine (SAMe) and is essential for cell division. Its combined intake with probiotics increases the production of short-chain fatty acids, propionic acid, butyrate, valeric and acetic acid – which promote gut health, good microbiome and overall health status, growth of the symbiotic species Actinobacteria and reduction of the number of the deleterious species Clostridia, hence promoting biodiversity and healthy gut microbiota.

Vitamin B12 (methylcobalamin) is the metabolically active form of the vitamin (and as effective as injections of hydroxocobalamin), essential in the developement, myelination, function of the central nervous system and has a crucial role to play in decreasing homocysteine, especially when combined with folate and pyridoxine.

Vitamin B12 improves mood and states of depression, as it helps in the synthesis and metabolism of serotonin. Low B12 levels lead to memory loss, cerebral atrophy and dementia. Combined supplementation with sources of DHA (omega-3 essential fatty acids) low cognitive decline. The bioavailability of B12 and its production by of the gut microbiota influence the production of acetylcholine.

Vitamin D

Vitamin D is involved in several brain cellular processes and there are specific vitamin receptors that are present in neurons and iglia, in areas of the brain that are involved in the pathophysiology of depression. Low levels of Vitamin D are found in depressed individuals.

Vitamin D deficiency affects about 80% of the population and is correlated with dysbiosis and inflammation. The use of supplementation increases significantly the diversity of the intestinal microbiotaand promotes the growth of symbiotic.

PLEXUSVITA formulations are specifically developed with active compounds that act as adjuvants in the treatment of diseases or symptoms of psychological and neurological origin; using highly effective and safe substances of natural origin.

All of these are scientifically studied and proven to promote and improve sleep quality, reduce anxiety and stress levels, and normalize the mood of depressed and apathetic individuals.

PLEXUSVITA presents exclusive formulations that promote better health and balance of all systems interconnected to the gut-brain axis.